Pair Name	Cordycepin, Anti-TIGIT antibody
Disease Info	[ICD-11: 2B90.Z]	Colon cancer		Investigative
Biological Phenomena	Reshaped-->Tumor immune microenvironment
Gene Regulation	Up-regulation	Expression	CD226	KEGG ID N.A.
In Vitro Model	MC-38	Mouse colon adenocarcinoma	Mus musculus (Mouse)	CVCL_B288
	CT26	Mouse colon adenocarcinoma	Mus musculus (Mouse)	CVCL_7254
In Vivo Model	1×10⁶ MC38 and CT26 cells were injected into the right abdomen of C57BL/6J and Balb/c mice.
Result	The combination therapy group increased DCs in the tumor immune microenvironment and promoted cellular interaction with CD4 T cell and CD8 T cell populations while decreasing Treg cell interactions. In conclusion, cordycepin with anti-TIGIT therapy in colon cancer could reshape the tumor immune microenvironment and have notable anticancer effects.